solid phase organic synthesis concepts strategies and applications pdf

Solid Phase Organic Synthesis Concepts Strategies And Applications Pdf

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In organic chemistry , peptide synthesis is the production of peptides , compounds where multiple amino acids are linked via amide bonds, also known as peptide bonds. Peptides are chemically synthesized by the condensation reaction of the carboxyl group of one amino acid to the amino group of another. Protecting group strategies are usually necessary to prevent undesirable side reactions with the various amino acid side chains. The chemical synthesis of peptides can be carried out using classical solution-phase techniques, although these have been replaced in most research and development settings by solid-phase methods see below. The established method for the production of synthetic peptides in the lab is known as solid-phase peptide synthesis SPPS.

Solid-Phase Organic Synthesis - E-bog

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A large number of organic, inorganic, or organic-inorganic hybrid materials have been employed as polymeric solid supports to promote or catalyze various organic reactions. The reaction parameters, scopes, and limitations, particularly in the context of green chemistry, have been highlighted with pertinent approaches by other groups. The concept of solid-phase organic synthesis SPOS dates back mids, and the solid-phase peptide synthesis in s developed by Merrifield has been a pioneering work [ 1 ]. Over the last two decades, there has been a surge generating tremendous interest in expanding this field of solid-phase synthesis [ 2 — 10 ]. There is a clear emphasis in synthetic chemistry towards developing environmentally friendly and sustainable routes to a myriad of materials. The emphasis is most apparent in the growth of green chemistry [ 11 — 14 ].

Solid-Phase Organic Synthesis Concepts, Strategies, and Applications

Wiley Online Library Probekapitel. Preis inkl. MwSt, zzgl. Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments.

Peptide synthesis

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Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality.

Solid-Phase Organic Synthesis

Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis.

Peptide synthesis

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Concepts, Strategies, and Applications

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